Newsletter January, 2016

GOOD WILL

Women for Cancer Research

New Scripps Florida Compound Successfully Targets Hard-to-Treat Breast Cancer Some good news about breast cancer from Scripps Florida. Findings from a new study suggest a potent new therapeutic approach for a number of hard-to-treat breast cancers.An enzyme called casein kinase 1δ (CK1δ) has emerged as a highly vulnerable therapeutic target. Increased expression of the enzyme is common to breast cancer, including the difficult-to-treat subtype called “triple negative breast cancer,” which affects 10 to 20 percent of breast cancer patients.

“The best news is that we have been able to treat CK1δ-expressing breast cancers with a highly selective and potent inhibitor developed by Bill Roush’s lab that triggers rapid tumor cell death,” said Derek Duckett, an associate professor on the Scripps Florida campus. The new compound, calledSR-3029, was remarkably successful at blocking the growth of tumors in both animal models and in studies with tumor tissue from breast cancer patients. “These results are just the tip of the iceberg,” said Roush, who is professor, associate dean and executive director of medicinal chemistry at Scripps Florida. “Inhibitors such as SR-3029 are being studied in a host of different cancers, and we are hopeful this platform can be translated into clinical applications.” The Frenchman's Creek Women for Cancer Research (WFCR) has raised over $1 million for Scripps Florida in support of the research being done in the Cancer Biology Department. WFCR has an ongoing partnership withThe Scripps Research Institute in the challenge of conquering women’s cancer through research....and this year’s schedule of events will help Scripps Florida get even closer to this goal. “Please join us for the first event of the new year on January 7 th for “Cocktails and Conversation” at the Scripps Research Institute hosted by the Women for Cancer Research (WFCR). Come meet world-class scientists and hear more about the amazing discoveries happening at Scripps Florida. For more information, please contact Stephanie Langlais at 561-228-2551 or slangla@scripps.edu.

There are many exciting events benefitting Scripps Research planned again this season. 1. Cocktail Reception and Auction on January 7 th at Scripps Florida.

2. Home Tours on January 24 th at Frenchman’s Creek. 3. Tennis and Pickleball Tournament on January 25 th . 4. Golf Tournament and Luncheon on January 26 th .

To learn more aboutWFCR and/or any of these events, please contact the Food and Beverage Office at 561-868-6370.

Newsletter                15             January 2016